2018年11月5日 JAACT2018 TSUKUBA

JAACT2018
https://www.aeplan.co.jp/jaact2018/

Symposium 2 Monday, November 5 (15:20-17:20)

Recent Advancements in Research on Aggregation and Immunogenicity of Therapeutic Proteins

Organizers: Susumu Uchiyama (Osaka University)

Akiko Ishii-Watabe (National Institute of Health Sciences (NIHS))

S2-1: Akiko Ishii-Watabe (National Institute of Health Sciences (NIHS))

S2-2: De Silva Ruckman (Food and Drug Administration (FDA))

S2-3: Srivalli Telikepalli (National Institute of Standard Technology (NIST))

S2-4: Constanze Helbig (Coriolis Pharma Research GmbH)

S2-5: Susumu Uchiyama (Osaka University)

It has been recently recognized that protein aggregates in biopharmaceuticals have potential to elicit immune responses and could possess the immunogenicity. Whereas, owing to recent development of analytical methods, aggregates ranging from nanometer to micron range can be properly monitored. In this symposium, current situation regarding to protein aggregation will be focused from two aspects, one is the characterization and control strategy of the aggregates, and another is the regulation of the aggregates.